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human alk2 proteins  (Sino Biological)


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    Structured Review

    Sino Biological human alk2 proteins
    Human Alk2 Proteins, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/acvr1/Human+ALK-2+ACVR1+ALK2+Protein/us12428484-804-25-34
    Average 93 stars, based on 6 article reviews
    human alk2 proteins - by Bioz Stars, 2026-09
    93/100 stars

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    Related Articles

    Fluorescence:

    Article Title: Multiregion single cell analysis reveals a novel subtype of cancer-associated fibroblasts located in the hypoxic tumor microenvironment in colorectal cancer
    Article Snippet: Co-staining of CRC tissues was performed using antibodies against COL11A1 (21841-1-AP, Proteintech, 1:100) and INHBA (10651-1-AP, Proteintech, 1:100). .. ACVR1(10227-T24, SinoBiological, 1:100), ACTA2 (19245, CST, 1:100), and CD44 (ab189524, Abcam, 1:100) were detected using a Four-color Fluorescence kit (Recordbio Biological Technology, Shanghai, China) based on the tyramide signal amplification (TSA) technology according to the manufacture's instruction. ..

    Amplification:

    Article Title: Multiregion single cell analysis reveals a novel subtype of cancer-associated fibroblasts located in the hypoxic tumor microenvironment in colorectal cancer
    Article Snippet: Co-staining of CRC tissues was performed using antibodies against COL11A1 (21841-1-AP, Proteintech, 1:100) and INHBA (10651-1-AP, Proteintech, 1:100). .. ACVR1(10227-T24, SinoBiological, 1:100), ACTA2 (19245, CST, 1:100), and CD44 (ab189524, Abcam, 1:100) were detected using a Four-color Fluorescence kit (Recordbio Biological Technology, Shanghai, China) based on the tyramide signal amplification (TSA) technology according to the manufacture's instruction. ..



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    Image Search Results


    Acvr1 ARC-R206H/+ ;R26 creERT2/creERT2 mice. (A) Genetic construct of Acvr1 ARC-R206H/+ knock-in allele (see text for additional description). (B) Experimental design showing the dosing and timing of Tamoxifen administration and assay time points. (C) Representative microCT images (VivaCT80) to detect mineralized bone at indicated days post-injury (dpi) by CTX injection. Arrow points to HO. n = 3 per time point. Scale bar = 5 mm. (D) Quantification of HO bone volume. Mean ± SEM displayed. n = 3. (E) Representative images of hind limb sections stained with H&E, Alcian Blue, and Orange G at indicated time points show immune cell infiltration (I) at 3 dpi, fibroproliferation (FP) at 7 dpi, and hypertrophic chondrocytes (C) with adjacent regions of (B) maturing heterotopic bone at 21 dpi. Scale bar = 50 μm for low magnification images (4×, top panel); 10 μm for high magnification images (40×, lower panel) (i-iii). Abbreviations: F, fibula; G, gastrocnemius; FP, fibroproliferation; C, chondrocytes; B, bone.

    Journal: JBMR Plus

    Article Title: An inducible knock-in mouse model of fibrodysplasia ossificans progressiva shows spontaneous formation of heterotopic ossification

    doi: 10.1093/jbmrpl/ziaf123

    Figure Lengend Snippet: Acvr1 ARC-R206H/+ ;R26 creERT2/creERT2 mice. (A) Genetic construct of Acvr1 ARC-R206H/+ knock-in allele (see text for additional description). (B) Experimental design showing the dosing and timing of Tamoxifen administration and assay time points. (C) Representative microCT images (VivaCT80) to detect mineralized bone at indicated days post-injury (dpi) by CTX injection. Arrow points to HO. n = 3 per time point. Scale bar = 5 mm. (D) Quantification of HO bone volume. Mean ± SEM displayed. n = 3. (E) Representative images of hind limb sections stained with H&E, Alcian Blue, and Orange G at indicated time points show immune cell infiltration (I) at 3 dpi, fibroproliferation (FP) at 7 dpi, and hypertrophic chondrocytes (C) with adjacent regions of (B) maturing heterotopic bone at 21 dpi. Scale bar = 50 μm for low magnification images (4×, top panel); 10 μm for high magnification images (40×, lower panel) (i-iii). Abbreviations: F, fibula; G, gastrocnemius; FP, fibroproliferation; C, chondrocytes; B, bone.

    Article Snippet: A total of 3 doses were given via intraperitoneal (i.p.) injections every 2 d. Acvr1 ARC-R206H/+ mice were crossed with mice double transgenic for Rosa26-rtTA and tetO-Cre (Gt(ROSA)26Sortm1(rtTA*M2)Jae and Tg(tetO-Cre)1Jaw; Jackson Laboratories 006965 and 006224) that express Cre recombinase in response to doxycycline.

    Techniques: Construct, Knock-In, Injection, Staining

    Acvr1 ARC-R206H/+ ;rt/rt;tetO-Cre mice. (A) Experimental design showing timing of doxycycline induction and assay time points. (B) Quantification of Acvr1 ARC-R206H/+ allele recombination from tail snips of mice after 5 d of doxycycline treatment. n = 15. (C) MicroCT images (VivaCT40) at indicated days post-injury (dpi) by CTX injection. Arrows point to HO. n = 3-5 per time point. Scale bar = 5 mm. (D) Quantification of heterotopic ossification (HO) bone volume. Graph represents the mean ± SEM. n = 3-5 per timepoint. (E) Representative images of hind limb sections stained with H&E, Alcian Blue, and Orange G at indicated time points showing (i) immune cell infiltration (I) at 3 dpi, (ii) fibroproliferation (FP) at 6 dpi), (iii) hypertrophic chondrocytes (C) at 10 dpi, and (iv) mature heterotopic bone (B) at 14 dpi. Scale bar = 50 μm for low magnification images (top panel); 10 μm for high magnification images (i-iv). Abbreviations: F, fibula; G, gastrocnemius; FP, fibroproliferation; C, chondrocytes; B, bone.

    Journal: JBMR Plus

    Article Title: An inducible knock-in mouse model of fibrodysplasia ossificans progressiva shows spontaneous formation of heterotopic ossification

    doi: 10.1093/jbmrpl/ziaf123

    Figure Lengend Snippet: Acvr1 ARC-R206H/+ ;rt/rt;tetO-Cre mice. (A) Experimental design showing timing of doxycycline induction and assay time points. (B) Quantification of Acvr1 ARC-R206H/+ allele recombination from tail snips of mice after 5 d of doxycycline treatment. n = 15. (C) MicroCT images (VivaCT40) at indicated days post-injury (dpi) by CTX injection. Arrows point to HO. n = 3-5 per time point. Scale bar = 5 mm. (D) Quantification of heterotopic ossification (HO) bone volume. Graph represents the mean ± SEM. n = 3-5 per timepoint. (E) Representative images of hind limb sections stained with H&E, Alcian Blue, and Orange G at indicated time points showing (i) immune cell infiltration (I) at 3 dpi, (ii) fibroproliferation (FP) at 6 dpi), (iii) hypertrophic chondrocytes (C) at 10 dpi, and (iv) mature heterotopic bone (B) at 14 dpi. Scale bar = 50 μm for low magnification images (top panel); 10 μm for high magnification images (i-iv). Abbreviations: F, fibula; G, gastrocnemius; FP, fibroproliferation; C, chondrocytes; B, bone.

    Article Snippet: A total of 3 doses were given via intraperitoneal (i.p.) injections every 2 d. Acvr1 ARC-R206H/+ mice were crossed with mice double transgenic for Rosa26-rtTA and tetO-Cre (Gt(ROSA)26Sortm1(rtTA*M2)Jae and Tg(tetO-Cre)1Jaw; Jackson Laboratories 006965 and 006224) that express Cre recombinase in response to doxycycline.

    Techniques: Injection, Staining

    Acvr1 ARC-R206H/+ ;rt/rt;tetO-Cre mice acquire non-injury induced HO. (A) Experimental design indicating timing of doxycycline induction and assay time points. (B) Whole-body microCT representative images (VivaCT40) 2, 3, and 4 wk after induction of mutation expression. Arrows point to HO. n = 3-5 per time point. Scale bar = 5 mm. (C) Quantification of HO volume at times post mutation induction. Data are plotted as mean ± SEM. n = 3-5. (D) Representative image stained with H&E, Alcian Blue, and Orange G at 4 wk post-mutation expression shows an example of new bone formation adjacent to spine with (i) cartilage formation (C) within skeletal muscle (M) and (ii) hypertrophic chondrocytes and new mineralized bone (B). Scale bar = 50 μm for low magnification image (4×, left panel); 10 μm for high magnification images (i and ii) (40×, right panels). Abbreviations: M, skeletal muscle; C, chondrocytes; B, bone.

    Journal: JBMR Plus

    Article Title: An inducible knock-in mouse model of fibrodysplasia ossificans progressiva shows spontaneous formation of heterotopic ossification

    doi: 10.1093/jbmrpl/ziaf123

    Figure Lengend Snippet: Acvr1 ARC-R206H/+ ;rt/rt;tetO-Cre mice acquire non-injury induced HO. (A) Experimental design indicating timing of doxycycline induction and assay time points. (B) Whole-body microCT representative images (VivaCT40) 2, 3, and 4 wk after induction of mutation expression. Arrows point to HO. n = 3-5 per time point. Scale bar = 5 mm. (C) Quantification of HO volume at times post mutation induction. Data are plotted as mean ± SEM. n = 3-5. (D) Representative image stained with H&E, Alcian Blue, and Orange G at 4 wk post-mutation expression shows an example of new bone formation adjacent to spine with (i) cartilage formation (C) within skeletal muscle (M) and (ii) hypertrophic chondrocytes and new mineralized bone (B). Scale bar = 50 μm for low magnification image (4×, left panel); 10 μm for high magnification images (i and ii) (40×, right panels). Abbreviations: M, skeletal muscle; C, chondrocytes; B, bone.

    Article Snippet: A total of 3 doses were given via intraperitoneal (i.p.) injections every 2 d. Acvr1 ARC-R206H/+ mice were crossed with mice double transgenic for Rosa26-rtTA and tetO-Cre (Gt(ROSA)26Sortm1(rtTA*M2)Jae and Tg(tetO-Cre)1Jaw; Jackson Laboratories 006965 and 006224) that express Cre recombinase in response to doxycycline.

    Techniques: Mutagenesis, Expressing, Staining